Multifunctional CAZymes have recently garnered a lot of attention due to their high cellulolytic activity, interesting deconstruction mechanisms, intramolecular synergy, and undeniable potential for industrial applications. Here we survey the natural diversity of multifunctional enzymes, especially those identified recently. We discuss the characterization of some of these multifunctional enzymes that can finally be isolated and characterized as full-length constructs, and finally, we review the industrial applicability of these multifunctional enzymes.